
-
All Black Ardie Savea to play for Japan's Kobe in 2026
-
Ohtani makes first pitching performance since 2023
-
Haliburton ready for 'backs against wall' NBA Finals test
-
Bank of Japan holds rates, says to slow bond purchase taper
-
Empty seats as Chelsea win opener at Club World Cup, Benfica deny Boca
-
G7 urges Iran de-escalation as Trump makes hasty summit exit
-
Verdict due for Sweden's 'Queen of Trash' over toxic waste
-
Israel, Iran trade missile fire as Trump warns Tehran to 'evacuate'
-
Thunder hold off Pacers to take 3-2 NBA Finals lead
-
Soft power: BTS fans rally behind Korean international adoptees
-
Dominant Flamengo open with victory at Club World Cup
-
Oil prices jump after Trump's warning, stocks extend gains
-
UK MPs eye decriminalising abortion for women in all cases
-
Yen slides ahead of Bank of Japan policy decision
-
Ecuador pipeline burst stops flow of crude
-
China's Xi in Kazakhstan to cement Central Asia ties
-
Despite law, US TikTok ban likely to remain on hold
-
Venezuela's El Dorado, where gold is currency of the poor
-
US forces still in 'defensive posture' in Mideast: White House
-
Trump makes hasty summit exit over Iran crisis
-
OpenAI wins $200 mn contract with US military
-
AFP photographer shot in face with rubber bullet at LA protest
-
Boca denied by two Argentines as Benfica fight back
-
Genflow Biosciences PLC Announces Corporate Update
-
Angle PLC - EACR 2025: Innovation in AR Expression Profiling
-
Rise in 'harmful content' since Meta policy rollbacks: survey
-
Trump to leave G7 early after warning of Iran attack
-
'Strange' to play in front of 50,000 empty seats: Chelsea's Maresca
-
Netanyahu says 'changing face of Middle East' as Israel, Iran trade blows
-
Mexican band accused of glorifying cartels changes its tune
-
G7 leaders urge Trump to ease off trade war
-
Trump presses Iran to talk but holds back on joint G7 call
-
Colombia presidential hopeful 'critical' after shooting
-
Main doctor charged in actor Matthew Perry overdose to plead guilty
-
Chelsea defeat LAFC in poorly-attended Club World Cup opener
-
Tiafoe crashes out, Rune cruises through at Queen's Club
-
Netanyahu says campaign 'changing face of Middle East' as Israel, Iran trade blows
-
What's not being discussed at G7 as Trump shapes agenda
-
UK apologises to thousands of grooming victims as it toughens law
-
Iran state TV briefly knocked off air by strike after missiles kill 11 in Israel
-
Trump urges Iran to talk as G7 looks for common ground
-
Canada wildfire near Vancouver contained
-
Four Atletico ultras get suspended jail for Vinicius effigy
-
England's top women's league to expand to 14 teams
-
Oil prices drop, stocks climb as Iran-Israel war fears ease
-
UN refugee agency says will shed 3,500 jobs due to funding cuts
-
US moves to protect all species of pangolin, world's most trafficked mammal
-
Kneecap 'unfazed' by legal problems, says friend and director
-
Electric fences, drones, dogs protect G7 leaders from bear attack
-
The name's Metreweli... Who is UK MI6's first woman chief?

Xenetic Biosciences, Inc. Enters into Clinical Trial Services Agreement with PeriNess Ltd. to Accelerate Development of DNase I Oncology Program
Collaboration utilizes PeriNess' expertise in clinical development of human recombinant DNase and bolsters efforts towards clinical proof-of-concept studies in multiple indications
Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing innovative immuno-oncology technologies addressing hard to treat cancers, today announced it has entered into a Clinical Trial Services Agreement (the "Agreement") with the Israel-based biotechnology company PeriNess Ltd. ("PeriNess") to advance the Company's development program for its systemic DNase I candidate in combination with chemotherapy and immunotherapy platforms for the treatment of pancreatic carcinoma, colorectal cancer and other locally advanced or metastatic solid tumors toward exploratory clinical studies.
"We are pleased to be working with PeriNess, and to have the opportunity to leverage their experience for the development of Xenetic's intravenous DNase I candidate through preclinical and early-stage clinical programs. We are excited to take this step forward on the path to the clinic and look forward to investigating our systemic DNase I candidate, XBIO-015, as an adjunctive treatment," commented James Parslow, Interim Chief Executive Officer and Chief Financial Officer of Xenetic.
"We are thrilled to enter this strategic Clinical Trial Services Agreement with Xenetic and further advance the development of their systemic DNase I platform. We believe this collaboration is a great example of where we can put substantial synergies from our projects toward accelerating the clinical development of a highly promising DNase I program for patients in need of new therapies," commented Michal Ben Attar, Chief Executive Officer of PeriNess.
A large body of published preclinical data highlights the pivotal role of Neutrophil Extracellular Traps (NETs) in modulating cancer chemotherapy and immunotherapy efficacy and provides a strong rationale for incorporating DNase I as an adjunctive treatment to improve therapeutic responses in patients with pancreatic and colorectal cancers receiving chemotherapy and immunotherapy.
Under the terms of the Agreement, PeriNess will lead in the regulatory approval, operational execution and management of potential exploratory, investigator initiated studies of recombinant DNase as an adjunctive treatment in patients with pancreatic carcinoma and other locally advanced or metastatic solid tumors receiving chemotherapy and immunotherapy in Israeli medical centers.
About PeriNess Ltd.
PeriNess, a pioneering privately held Israeli company, is at the forefront of developing innovative solutions for male infertility. The company is developing a novel drug based on DNase I, which has shown potential to improve sperm quality and increase the chances of conception. PeriNess preclinical studies have shown that Neutrophil Extracellular Traps (NETs) in the blood is the deleterious factor triggering sperm damage and have confirmed that DNase treatment reduces levels of NETs in the blood, prevents sperm cell damage and improves sperm quality. With the recent completion of its Phase 1 clinical trial in Israel, PeriNess is now advancing DNase I to Phase 2 clinical trials, aiming to bring a groundbreaking new treatment to millions of couples struggling with infertility.
About Xenetic Biosciences
Xenetic Biosciences, Inc. is a biopharmaceutical company focused on advancing innovative immune-oncology technologies addressing hard to treat cancers. The Company's DNase I platform is designed to improve outcomes of existing treatments, including immunotherapies, by targeting neutrophil extracellular traps (NETs), which are involved in cancer progression. Xenetic is currently focused on advancing its systemic DNase program into the clinic as an adjunctive therapy for pancreatic carcinoma , colorectal cancer and locally advanced or metastatic solid tumors.
For more information, please visit the Company's website at www.xeneticbio.com and connect on X, LinkedIn, and Facebook.
Forward-Looking Statements
This press release contains forward-looking statements that we intend to be subject to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release other than statements of historical facts may constitute forward-looking statements within the meaning of the federal securities laws. These statements can be identified by words such as "expects," "plans," "projects," "will," "may," "anticipates," "believes," "should," "intends," "estimates," and other words of similar meaning, including, but not limited to, statements regarding: the Agreement with PeriNess, including that such collaboration will bolster efforts towards clinical proof-of-concept studies in multiple indications and advance the Company's development program for its systemic DNase I candidate in combination with chemotherapy and immunotherapy platforms for the treatment of pancreatic carcinoma, colorectal cancer and other locally advanced or metastatic solid tumors toward exploratory clinical studies, statements regarding the role of PeriNess under the Agreement, statements regarding the opportunity to leverage PeriNess's experience for the development of intravenous DNase I candidate through preclinical and early-stage clinical programs, and statements regarding our excitement to take this step forward on the path to the clinic and investigating our systemic DNase I candidate, XBIO-015, as an adjunctive treatment, as well as all statements regarding expectations for our DNase-base oncology platform, including our focus on advancing our systemic DNase program into the clinic as an adjunctive therapy for pancreatic carcinoma and locally advanced or metastatic solid tumors. Any forward-looking statements contained herein are based on current expectations and are subject to a number of risks and uncertainties. Many factors could cause our actual activities, performance, achievements, or results to differ materially from the activities and results anticipated in forward-looking statements. Important factors that could cause actual activities, performance, achievements, or results to differ materially from such plans, estimates or expectations include, among others, (1) unexpected costs, charges or expenses resulting from our manufacturing and collaboration agreements, including the Agreement with PeriNess; (2) unexpected costs, charges or expenses resulting from the licensing of the DNase platform; (3) uncertainty of the expected financial performance of the Company following the licensing of the DNase platform; (4) failure to realize the anticipated potential of the DNase, XCART or PolyXen technologies; (5) the ability of the Company to obtain funding and implement its business strategy; and (6) other risk factors as detailed from time to time in the Company's reports filed with the SEC, including its annual report on Form 10-K, periodic quarterly reports on Form 10-Q, current reports on Form 8-K and other documents filed with the SEC. The foregoing list of important factors is not exclusive. In addition, forward-looking statements may also be adversely affected by general market factors, general economic and business conditions, including potential adverse effects of public health issues, such as the COVID-19 outbreak, and geopolitical events, such as the conflicts in the Ukraine and in the Middle East, on economic activity, competitive product development, product availability, federal and state regulations and legislation, the regulatory process for new product candidates and indications, manufacturing issues that may arise, patent positions, litigation and shareholder activism, among other factors. The forward-looking statements contained in this press release speak only as of the date the statements were made, and the Company does not undertake any obligation to update forward-looking statements, except as required by law.
Contact:
JTC Team, LLC
Jenene Thomas
(908) 824-0775
xbio@jtcir.com
SOURCE: Xenetic Biosciences, Inc.
G.Stevens--AMWN